Biology and Pathology of Trophoblast胚胎滋养层生物学和病理学 txt umd azw3 下载 fb2 pdf 在线 免费

　　“Readers who want a more scientific treatise on the wonders of the placenta should peruse Biology and Pathology of Trophoblast。provide succinct yet comprehensive introductions to a number of important immunologic concepts pertinent to the process of placentation and the maintenance of pregnancy。 Many interesting facts about placental immunology are shared。”

Drucilla J.Robers，M.D.， Massachusetts General Hospital， New England Journal of Medicine。

This is the first dedicated， in-depth account of trophoblast: the tissue derived from the fertilized egg that nourishes and protects the developing fetus。 The cells of the trophoblast have many unique qualities， and exhibit great variability across different species。 It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo。 These aspects are all fully covered as well as studies on why it is not rejected by the mother as ‘foreign’ tissue。 This volume provides an up-to-date summary of the state of current knowledge and offers some glimpses as to future development on the scientific and clinical front。

List of contributors

List of participants

Preface

Y.W.（Charlie） Loke

Chair’s introduction

　1　Trophoblast cell fate specification

　2　Stem cells: pluripotency and extraembryonic differentiation　in the mouse

　3　Epigenetic regulation of trophoblast development

　4　Regulation of X-chromosome inactivation in relation to lineage　allocation in early mouse embryogenesis

General discussion Ⅰ

　5　Gestational trophoblastic disease

　6　Trophoblast and the first trimester environment

　7　Implantation is a sticky situation

　8　Trophoblast regulation of maternal endocrine function　and behaviour

General discussion Ⅱ

　9　Molecular signalling in embryo-uterine interactions　during implantation

　10　Trophoblast and pre-eclampsia

　11　Trophoblast and uterine mucosal leukocytes

　12　Immunology of trophoblast： a reappraisal

Final general discussion

Index

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书籍介绍

Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.